The authors investigated the association between maternal preconceptional supplemental and dietary zinc intake and risk of neural tube defects (NTDs) in a population-based case-control study conducted between 1989 and 1991 in California.
Cases were 430 NTD-affected fetuses/infants, and controls were 429 randomly selected non-malformed infants.
Mothers reported their preconceptional use of vitamin, mineral, and food supplements, and completed a 98-item food frequency questionnaire.
Increased total preconceptional zinc intake was associated with a reduced risk for NTDs (quintile 5 vs. quintile 1, odds ratio (OR)=0.65,95% confidence interval (Cl) 0.43,0.99).
Phytate intake, a constituent of the diet known to impede zinc absorption, appeared to modify the zinc - NTD association.
In addition, increased servings of animal products, the most bioavailable food source of zinc, was associated with a reduced risk for NTDs (quintile 5 vs. quintile 1, OR=0.49,95% Cl 0.32,0.76).
Risk estimates for zinc intake were changed little after controlling for multiple sociodemographic factors and total folate intake, but were attenuated after controlling for nutrients highly correlated with dietary sources of zinc, such as protein.
In sum, the analyses indicate that risk of NTDs in infants and fetuses decreased with increasing maternal preconceptional zinc intake. (...)
Mots-clés Pascal : Anencéphalie, Spina bifida, Maladie congénitale, Malformation, Tube neural, Zinc, Régime alimentaire, Mère, Supplémentation, Epidémiologie, Facteur risque, Prévention, Incidence, Nouveau né, Homme, Californie, Etats Unis, Amérique du Nord, Amérique, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie, Système ostéoarticulaire pathologie, Rachis pathologie
Mots-clés Pascal anglais : Anencephaly, Spina bifida, Congenital disease, Malformation, Neural tube, Zinc, Diet, Mother, Supplementation, Epidemiology, Risk factor, Prevention, Incidence, Newborn, Human, California, United States, North America, America, Nervous system diseases, Central nervous system disease, Cerebral disorder, Diseases of the osteoarticular system, Spine disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0483693
Code Inist : 002B20F02. Création : 22/03/2000.