The authors investigated the recurrence risk of congenital anomalies as a function of changes in genetic and environmental factors in single births following the birth of a child with an anomaly.
The study is a population-based historical follow-up using the Danish Medical Birth registry, hospital discharge diagnoses, and Statistic Denmark's Fertility Database.
The investigators identified 8,671 women who gave birth to a child with a diagnosed malformation between 1980 and 1992 and had a subsequent birth.
Following the birth of an affected infant, 474 (5.5%) women gave birth to another child with a malformation, 155 of which (1.8%) were similar to the malformation of the older sib or half sib.
When the father changed between the two births, the risk of a similar anomaly was significantly reduced (odds ratio (OR)=0.26,95% confidence interval (Cl) 0.11,0.65).
Higher social status at enrollment was associated with a lower recurrence risk (OR=0.67,95% CI 0.45,0.99, for the middle status group and OR=0.49,95% Cl 0.30,0.81, for the highest status group), independently of partner change.
A rise in social status between the two births was marginally associated with a decline in the recurrence risk.
No variation in the recurrence risk associated with change of municipality or occupation was seen.
Mots-clés Pascal : Maladie congénitale, Anomalie, Statut socioéconomique, Classe sociale, Santé et environnement, Exposition, Père, Epidémiologie, Facteur risque, Nouveau né, Homme, Danemark, Europe, Gestation pathologie, Foetus pathologie, Nouveau né pathologie
Mots-clés Pascal anglais : Congenital disease, Anomaly, Socioeconomic status, Social class, Health and environment, Exposure, Father, Epidemiology, Risk factor, Newborn, Human, Denmark, Europe, Pregnancy disorders, Fetal diseases, Newborn diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0483692
Code Inist : 002B20F02. Création : 22/03/2000.