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  1. Fulltext. Recurrence risk of congenital anomalies : the impact of paternal, social, and environmental factors : A population-based study in Denmark.

    Article - En anglais


    The authors investigated the recurrence risk of congenital anomalies as a function of changes in genetic and environmental factors in single births following the birth of a child with an anomaly.

    The study is a population-based historical follow-up using the Danish Medical Birth registry, hospital discharge diagnoses, and Statistic Denmark's Fertility Database.

    The investigators identified 8,671 women who gave birth to a child with a diagnosed malformation between 1980 and 1992 and had a subsequent birth.

    Following the birth of an affected infant, 474 (5.5%) women gave birth to another child with a malformation, 155 of which (1.8%) were similar to the malformation of the older sib or half sib.

    When the father changed between the two births, the risk of a similar anomaly was significantly reduced (odds ratio (OR)=0.26,95% confidence interval (Cl) 0.11,0.65).

    Higher social status at enrollment was associated with a lower recurrence risk (OR=0.67,95% CI 0.45,0.99, for the middle status group and OR=0.49,95% Cl 0.30,0.81, for the highest status group), independently of partner change.

    A rise in social status between the two births was marginally associated with a decline in the recurrence risk.

    No variation in the recurrence risk associated with change of municipality or occupation was seen.

    Mots-clés Pascal : Maladie congénitale, Anomalie, Statut socioéconomique, Classe sociale, Santé et environnement, Exposition, Père, Epidémiologie, Facteur risque, Nouveau né, Homme, Danemark, Europe, Gestation pathologie, Foetus pathologie, Nouveau né pathologie

    Mots-clés Pascal anglais : Congenital disease, Anomaly, Socioeconomic status, Social class, Health and environment, Exposure, Father, Epidemiology, Risk factor, Newborn, Human, Denmark, Europe, Pregnancy disorders, Fetal diseases, Newborn diseases

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0483692

    Code Inist : 002B20F02. Création : 22/03/2000.