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  1. A comparison of C/B ratios from studies using receiver operating characteristic curve analysis.

    Article - En anglais

    In receiver operating characteristic (ROC) curve analysis, the optimal cutoff value for a diagnostic test can be found on the ROC curve where the slope of the curve is equal to (C/B) x (1-p[D])/p[D], where p[D] is the disease prevalence and C/B is the ratio of net costs of treating nondiseased individuals to net benefits of treating diseased individuals.

    We conducted a structured review of the medical literature to examine C/B ratios found in ROC curve analysis.

    Only two studies were found in which a C/B ratio was explicitly calculated ; in another 11 studies, a C/B ratio was based on a so-called holistic estimate, an all-encompassing educated estimate of the relative costs and benefits relevant to the clinical situation.

    The C/B ratios ranged from 0.0025 (tuberculosis screening) to 2.7 (teeth restoration for carious lesions).

    Clinical scenarios that are directly life threatening but curable had C/B ratios of less than 0.05.

    This analysis led us to construct a table of ordered C/B ratios that may be used by investigators to approximate C/B ratios for other clinical situations in order to establish cutpoints for new diagnostic tests.

    Mots-clés Pascal : Méthode ROC, Diagnostic, Technique, Examen laboratoire, Validation test, Spécificité, Sensibilité, Ratio, Epidémiologie, Méthodologie, Evaluation performance, Analyse avantage coût, Homme, Prise décision, Etude comparative

    Mots-clés Pascal anglais : Receiver operating characteristic curves, Diagnosis, Technique, Laboratory investigations, Test validation, Specificity, Sensitivity, Ratio, Epidemiology, Methodology, Performance evaluation, Cost benefit analysis, Human, Decision making, Comparative study

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0483518

    Code Inist : 002B30A01A1. Création : 22/03/2000.