Between July 1992 and June 1996,901 new cases of adult acute lymphoblastic leukaemia were recorded in the GIMEMA Archive of Adult Acute Leukaemia ; 21 of them (2.3%) had a previous primary malignancy (PM).
We found that secondary acute lymphoblastic leukaemia cases (sALL) presented with older age, a high incidence of pre-pre-B immunophenotype and a significantly higher prevalence of cancer among relatives compared to de novo ALL.
The leukaemogenic activity of the cytotoxic drugs employed for the treatment of PM may have played a potential role in only a proportion of patients, opening the possibility that some sALL patients may have developed two or more malignancies due to individual predisposing factors.
Mots-clés Pascal : Leucémie lymphoblastique, Second cancer, Epidémiologie, Chimiothérapie, Anticancéreux, Radiothérapie, Italie, Europe, Homme, Aigu, Hémopathie maligne, Lymphoprolifératif syndrome
Mots-clés Pascal anglais : Acute lymphocytic leukemia, Second cancer, Epidemiology, Chemotherapy, Antineoplastic agent, Radiotherapy, Italy, Europe, Human, Acute, Malignant hemopathy, Lymphoproliferative syndrome
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0482968
Code Inist : 002B19B. Création : 22/03/2000.