Glutathione S-transferase M1 genotypes and the risk of squamous carcinoma of the cervix : A population-based case-control study.
The authors determined the GSTM1 genotype of 190 Caucasian women with invasive squamous cell cervical cancer in western Washington State between January 1986 and June 1994 and of 206 controls.
It was found that 53% of cases and 57% of controls had the GSTM1 null genotype.
The age-adjusted odds ratio associated with GSTM1 null genotype was 0.8 (95% confidence interval 0.6,1.3).
The lack of association between cervical cancer risk and GSTM1 genotype was true both for smokers and nonsmokers of cigarettes and for heavy and light smokers.
These data suggest that women with the GSTM1 null genotype are not at increased risk of cervical cancer.
Am J Epidemiol 1999 ; 150 : 568-72.
Mots-clés Pascal : Tumeur maligne, Col utérus, Glutathione transferase, Transferases, Enzyme, Marqueur biologique, Génotype, Epidémiologie, Facteur risque, Homme, Femelle, Etats Unis, Amérique du Nord, Amérique, Etude cas témoin, Appareil génital femelle pathologie, Col utérus pathologie
Mots-clés Pascal anglais : Malignant tumor, Uterine cervix, Glutathione transferase, Transferases, Enzyme, Biological marker, Genotype, Epidemiology, Risk factor, Human, Female, United States, North America, America, Case control study, Female genital diseases, Uterine cervix diseases
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0482257
Code Inist : 002B20C02. Création : 22/03/2000.