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  1. Fulltext. Controls who experienced hypothetical causal intermedi hould not be excluded from case-control studies.

    Article - En anglais


    It has been suggested that controls with adenematous polyps of the colon and rectum should be excluded from case-control studies of cigarette smoking and colorectal cancer.

    A claim has been made that the presence of such controls creates a bias toward the null.

    The polyps are an intermediate step in a hypothetical causal pathway between the exposure and the disease.

    Thus, the recommendation logically extends to the exclusion of all controls who experienced hypothetical causal intermediates from all case-control studies.

    It is shown, in the simple case of an exposure that acts solely through the pathway involving the intermediate, that such exclusions create a bias away from the null.

    The rationale for recommending the detrimental exclusions appears to stem from a variant of the « trohoc fallacy » : the mistaken view of case-control studies as comparisons between diseased and healthy groups and not as comparisons between groups that differ by exposure.

    Mots-clés Pascal : Etude cas témoin, Tumeur maligne, Côlon, Rectum, Tabagisme, Polype, Facteur risque, Epidémiologie, Méthodologie, Homme, Appareil digestif pathologie, Intestin pathologie, Côlon pathologie, Rectum pathologie, Tumeur bénigne

    Mots-clés Pascal anglais : Case control study, Malignant tumor, Colon, Rectum, Tobacco smoking, Polyp, Risk factor, Epidemiology, Methodology, Human, Digestive diseases, Intestinal disease, Colonic disease, Rectal disease, Benign neoplasm

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0482255

    Code Inist : 002B13B01. Création : 22/03/2000.