logo BDSP

Base documentaire

  1. Changes in seroepidemiological pattern of Helicobacter pylori and hepatitis A virus over the last 20 years in Japan.

    Article - En anglais


    The age groups most susceptible to infection and the mode of transmission of Helicobacter pylori (H. pylori) are not yet clear.

    To contribute to a better understanding of this disease, this study was undertaken to evaluate changes in the seroepidemiological pattern of H. pylori in a group of Japanese people over the last 20 yr sampled in 1974,1984, and 1994 in comparison with that of the hepatitis A virus (HAV), which was used as a marker of the fecal-oral route of transmission.


    A total of 1015 serum samples were obtained from the National Institute of Infectious Diseases in Tokyo.

    All of these samples were from healthy persons aged 0-89 yr (442 male and 573 female ; median age 35.6 yr), living in seven prefectures in the central part of Japan in 1974,1984, and 1994.

    All serum samples were assayed for H. pylori IgG by means of enzyme-linked immunosorbent assay (ELISA).

    Further, anti-HAV antibodies were assayed by blocking ELISA in the same samples.

    We investigated the prevalence of H. pylori and HAV for all ages, and the positive rate of H. pylori for infants and children separately.


    The overall prevalence of H. pylori antibodies was 72.7% (CI 95%, 68.0-77.3) in 1974,54.6% (CI 95%, 49.1-60.0) in 1984 and 39.3% (CI 95%, 34.1-44.4) in 1994.

    That of HAV was 57.7% (CI 95%, 52.5-62.8) in 1974,41.7% (CI 95%, 36.3-47.0) in 1984, and 23.4% (CI 95%, 18.9-27.8) in 1994.

    The prevalence of both H. (...)

    Mots-clés Pascal : Sérologie, Epidémiologie, Virose, Infection, Virus hépatite A, Hepatovirus, Picornaviridae, Virus, Bactériose, Helicobacter pylori, Spirillaceae, Spirillales, Bactérie, Prévalence, Analyse temporelle, Homme, Japon, Asie

    Mots-clés Pascal anglais : Serology, Epidemiology, Viral disease, Infection, Hepatitis A virus, Hepatovirus, Picornaviridae, Virus, Bacteriosis, Helicobacter pylori, Spirillaceae, Spirillales, Bacteria, Prevalence, Time analysis, Human, Japan, Asia

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0481993

    Code Inist : 002B30A01A2. Création : 22/03/2000.