Disturbance of cerebral function in people exposed to drinking water contaminated with aluminium sulphate : retrospective study of the Camelford water incident.
Objective To establish whether people exposed to drinking water contaminated with 20 tonnes of aluminium sulphate in the Camelford area of Cornwall in the south west of England in July 1988 had suffered organic brain damage as opposed to psychological trauma only.
Design Retrospective study of affected people.
Participants 55 affected people and 15 siblings nearest in age to one of the group but who had not been exposed to the contaminated water were studied.
Main outcome measures Various clinical and psychological tests to determine medical condition and anxiety levels in affected people.
Assessment of premorbid IQ (pFSIQ) with the national adult reading test, a computerised battery of psychomotor testing, and measurement of the difference in latencies between the flash and pattern visual evoked potentials in all participants.
Results The mean (SE) pFSIQ was above average at 114.4 (1.1).
The most sensitive of the psychomotor tests for organic brain disease was the symbol digit coding (SDC) test (normal score 100, abnormal<85).
Participants performed less well on this test (54.5 (6.0)) than expected from their pFSIQ (P<0.0001) and a little less poorly on the averaged less discriminating tests within the battery (86.1 (2.5), P<0.0001).
In a comparison with the 15 sibling pairs (affected people's age 41.0 (3.3) years upsilon sibling age of 42.7 (3.1) years (P=0.36) the exposed people had similar pFSIQ (114.7 (2.1)) to their siblings (116.3 (2.1) (...)
Mots-clés Pascal : Royaume Uni, Europe, Epidémiologie, Homme, Santé, Santé et environnement, Contamination, Toxicité, Eau potable, Aluminium sulfate, Exploration clinique, Test Psychomotricité, Potentiel évoqué visuel, Quotient intellectuel, Pollution, Test psychologique
Mots-clés Pascal anglais : United Kingdom, Europe, Epidemiology, Human, Health, Health and environment, Contamination, Toxicity, Drinking water, Aluminium sulfate, Clinical investigation, Test Psychomotricité, Visual evoked potential, Intelligence quotient, Pollution
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0481066
Code Inist : 002B30A01A2. Création : 22/03/2000.