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  1. Cancer, heart disease, and diabetes in workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin.

    Article - En anglais


    In 1997, the International Agency for Research on Cancer classified 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) as a group 1 human carcinogen, based largely on four highly exposed industrial cohorts that showed an excess of all cancers combined.

    In this study, we extended the follow-up period for the largest of these cohorts by 6 years and developed a job-exposure matrix.


    We did cohort mortality analyses involving 5132 chemical workers at 12 U.S. plants by use of life table techniques (U.S. population referent) and Cox regression (internal referent).

    We conducted exposure-response analyses for 69% of the cohort with adequate work history data and adequate plant data on TCDD contamination.

    All P values are two-sided.


    The standardized mortality ratio (SMR) for all cancers combined was 1.13 (95% confidence interval=1.02-1.25).

    We found statistically significant positive linear trends in SMRs with increasing exposure for all cancers combined and for lung cancer.

    The SMR for all cancers combined for the highest exposure group was 1.60 (95% confidence interval=1.15-1.82).

    SMRs for heart disease showed a weak increasing trend with higher exposure (P=14).

    Diabetes (any mention on the death certificate) showed a negative exposure-response trend.

    Internal analyses with Cox regression found statistically significant trends for cancer (15-year lag time) and heart disease (no lag). (...)

    Mots-clés Pascal : Maladie professionnelle, Exposition professionnelle, Facteur risque, Dioxine dérivé, Tumeur maligne, Epidémiologie, Diabète, Incidence, Etude cohorte, Cardiopathie, Carcinogène, Endocrinopathie, Appareil circulatoire pathologie

    Mots-clés Pascal anglais : Occupational disease, Occupational exposure, Risk factor, Dioxin derivatives, Malignant tumor, Epidemiology, Diabetes mellitus, Incidence, Cohort study, Heart disease, Carcinogen, Endocrinopathy, Cardiovascular disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0477370

    Code Inist : 002B30B01A. Création : 22/03/2000.