Future cardiovascular end point studies : Where will the research take us ?
Coronary artery disease is the most common cause of death in the world.
Emerging concepts of atherosclerosis imply that atherosclerosis is a diffuse disease, and cannot be definitively treated with local, anatomic interventions, such as coronary artery bypass graft surgery or angioplasty.
Cholesterol lowering, on the other hand, has been shown to dramatically ower the rate of both morbid and mortal coronary events.
In trials with new statin drugs, coronary risk has been lowered by approximately 30%. Additional risk reduction will require other approaches, including (1) intervention for other risk factors, (2) more aggressive cholesterol lowering, or (3) increased attention to primary prevention.
The last requires a combination of public health measures to change harmful diet and life-style patterns as well as case findings to identify and treat at-risk subjects.
For all these approaches, measures that will increase compliance by both physicians and patients to regimens with proven benefits are required.
Mots-clés Pascal : Athérosclérose, Cardiopathie coronaire, Hypercholestérolémie, Prévention, Facteur risque, Homme, Lipide, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Métabolisme pathologie, Dyslipémie, Hyperlipoprotéinémie
Mots-clés Pascal anglais : Atherosclerosis, Coronary heart disease, Hypercholesterolemia, Prevention, Risk factor, Human, Lipids, Cardiovascular disease, Vascular disease, Metabolic diseases, Dyslipemia, Hyperlipoproteinemia
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0477131
Code Inist : 002B12A03. Création : 22/03/2000.