Quantification of the dose of inhaled flour : relation with nonspecific bronchial and immunological reactivities.
The aim of this study was to investigate the relationship between specific bronchial reactivity and respective nonspecific bronchial and immunological reactivities.
Twenty-one patients underwent bronchial challenges with lactose and flour.
The aerosol of particles was generated by a computer-controlled aerosolizer.
Specific bronchial challenge results were expressed as the provocative dose of flour (PDf) that caused a 20% or 15% decrease in the forced expiratory volume in one second (FEV1).
For each subject, the decrease in FEV1 observed during the challenge with flour was compared with the calculated lower limit of the 99.7% confidence interval for the lactose challenge.
The subjects also underwent a nonspecific challenge with methacholine and a measurement of the specific immunoglobulin E against wheat.
The inhalation of lactose did not significantly affect FEV1.
Nine subjects had high reactivity to wheat flour with a PDf20<400 mug.
Five subjects had intermediate reactivity :
FEV1 fell by<20% but by significantly more than that in the test with lactose.
For 7 subjects, there was no significant change in FEV1 for inhaled doses of flour over 1390 mug.
The results for specific bronchial challenge were significantly correlated with those for the methacholine test (p<0.02).
Positive skin tests and specific immunoglobulin E against wheat were observed more frequently in the high reactivity group. (...)
Mots-clés Pascal : Asthme, Allergie, Maladie professionnelle, Farine blé, Inhalation, Test provocation, Relation dose réponse, Fonction respiratoire, Hyperréactivité, Bronche, Exploration, Homme, Appareil respiratoire pathologie, Bronchopneumopathie obstructive, Immunopathologie, Médecine travail
Mots-clés Pascal anglais : Asthma, Allergy, Occupational disease, Wheat flour, Inhalation, Provocation test, Dose activity relation, Lung function, Hyperreactivity, Bronchus, Exploration, Human, Respiratory disease, Obstructive pulmonary disease, Immunopathology, Occupational medicine
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0475690
Code Inist : 002B06C02. Création : 22/03/2000.