Correcting for exposure measurement error in a reanalysis of lung cancer mortality for the Colorado Plateau Uranium Miners cohort.
The exposure estimates used to date for the analysis of lung cancer mortality in the Colorado Plateau Uranium Miners cohort were developed from radon progeny measurements taken in mines beginning in 1951.
Since uranium miners were often exposed over long periods of time and since mines were not continuously monitored, much extrapolation and/or interpolation of measured dose-rates was needed in order to develop estimates of exposure for each of the miners in the cohort.
We have recently re-examined the interpolation scheme used to create the histories in the light of the fit of a statistical model for the radon progeny measurements taken in mines within the Plateau, and we have computed revised exposure estimates for the large majority of miners in the cohort.
This report describes the use of these new model-based revised exposure estimates in the analysis of lung cancer mortality, using follow-up data current through 1990.
Specific issues addressed here are (1) the strength of the association between exposure and risk of lung cancer mortality ; (2) effects of attained age and time since exposure upon risk of lung cancer mortality ; and (3) exposure-rate effects upon risk.
Results using the revised exposure estimates are compared to those obtained fitting the same models using the original Public Health Service (PHS) exposure estimates. (...)
Mots-clés Pascal : Etude cohorte, Mineur, Exposition professionnelle, Irradiation ionisante, Etats Unis, Amérique du Nord, Amérique, Colorado, Tumeur maligne, Bronchopulmonaire, Mortalité, Dosimétrie, Technique mesure, Biais méthodologique, Maladie professionnelle, Appareil respiratoire pathologie, Poumon pathologie, Bronche pathologie
Mots-clés Pascal anglais : Cohort study, Minor, Occupational exposure, Ionizing irradiation, United States, North America, America, Colorado, Malignant tumor, Bronchopulmonary, Mortality, Dosimetry, Measurement technique, Methodological bias, Occupational disease, Respiratory disease, Lung disease, Bronchus disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0475417
Code Inist : 002B30B01B. Création : 22/03/2000.