Aim The aim of this study was to assess the prevalence of diabetes mellitus in patients with hepatitis C virus (HCV) chronic hepatitis and secondary haemochromatosis as a consequence of bêta-thalassaemia major.
This group of patients was studied in order to reveal subtle effects of early stages of HCV infection on glucose metabolism, made more apparent by the coexistence of the diabetogenic effect of haemochromatosis.
Patients and methods The study included 108 bêta-thalassaemic multitransfused patients, 55 females and 53 males, age 26.8 ± 9 years.
Sixty-four patients were seropositive for HCV by ELISA-3 (61/64 HCV-polymerase chain reaction-positive by Amplicor).
In 51 of these, chronic hepatitis C was documented by liver biopsy, which also showed incomplete cirrhosis for eight and cirrhosis for four patients.
Diabetes was diagnosed according to the criteria of the National Diabetes Data Group of the National Institutes of Health.
Results (1) Patients with thalassaemia and HCV infection were diabetic more often than thalassaemic patients without HCV Infection (45.3% versus 11.3% ; P<0.001).
This highly significant difference was also found when patients with definite cirrhosis or incomplete cirrhosis were excluded (41% versus 11.3% ; P<0.01). (...)
Mots-clés Pascal : Diabète, Prévalence, Haute fréquence, Hépatite virale C, Virose, Infection, Chronique, Association, Thalassémie bêta, Complication, Critère sélection, Hémochromatose, Etude comparative, Base donnée, Résultat, Homme, Fer, Endocrinopathie, Appareil digestif pathologie, Foie pathologie, Hémopathie, Anémie hémolytique, Hémoglobinopathie, Maladie héréditaire, Métabolisme pathologie, Enzymopathie
Mots-clés Pascal anglais : Diabetes mellitus, Prevalence, High frequency, Viral hepatitis C, Viral disease, Infection, Chronic, Association, bêta-Thalassemia, Complication, Selection criterion, Hemochromatosis, Comparative study, Database, Result, Human, Iron, Endocrinopathy, Digestive diseases, Hepatic disease, Hemopathy, Hemolytic anemia, Hemoglobinopathy, Genetic disease, Metabolic diseases, Enzymopathy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0475414
Code Inist : 002B21E01B. Création : 22/03/2000.