Alcohol and smoking as risk factors in chronic pancreatitis and pancreatic cancer.
The aim of this study was to compare alcohol and smoking as risk factors in the development of chronic pancreatitis and pancreatic cancer.
We considered only male subjects
(1) 630 patients with chronic pancreatitis who developed 12 pancreatic and 47 extrapancreatic cancers ; (2) 69 patients with histologically well documented pancreatic cancer and no clinical history of chronic pancreatitis ; and (3) 700 random controls taken from the Verona polling list and submitted to a complete medical check-up.
Chronic pancreatitis subjects drink more than control subjects and more than subjects with pancreatic cancer without chronic pancreatitis (P<0.001).
The percentage of smokers in the group with chronic pancreatitis is significantly higher than that in the control group [odds ratio (OR) 17.3 ; 95% CI 12.6-23.8 ; P<0.001] and in the group with pancreatic carcinomas but with no history of chronic pancreatitis (OR 5.3 ; 95% CI 3.0-9.4 ; P<0.001).
In conclusion, our study shows that
(1) the risk of chronic pancreatitis correlates both with alcohol intake and with cigarette smoking with a trend indicating that the risk increases with increased alcohol intake and cigarette consumption ; (2) alcohol and smoking are statistically independent risk factors for chronic pancreatitis ; and (3) the risk of pancreatic cancer correlates positively with cigarette smoking but not with drinking.
Mots-clés Pascal : Tumeur maligne, Pancréas, Association, Pancréatite, Chronique, Epidémiologie, Alcoolisme, Tabagisme, Etude comparative, Facteur risque, Evaluation, Homme, Italie, Europe, Appareil digestif pathologie, Pancréas pathologie, Toxicologie
Mots-clés Pascal anglais : Malignant tumor, Pancreas, Association, Pancreatitis, Chronic, Epidemiology, Alcoholism, Tobacco smoking, Comparative study, Risk factor, Evaluation, Human, Italy, Europe, Digestive diseases, Pancreatic disease, Toxicology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0475202
Code Inist : 002B13C01. Création : 22/03/2000.