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  1. Age, gender, and local geographic variations of viral etiology of hepatocellular carcinoma in a hyperendemic area for hepatitis B virus infection.

    Article - En anglais


    There are etiologic variations of hepatocellular carcinoma (HCC) in different geographic areas.

    Taiwan is a hyperendemic area for hepatitis B virus (HBV) infection.

    Hepatitis C virus (HCV) infection also plays an important role in HCC development in Taiwan.

    Identification of local HCV-endemic areas is important to keep HCV from spreading.

    This study investigated the etiologic variations of HCC in different geographic areas of Taiwan.


    The authors evaluated the hepatitis B surface antigen (HBsAg) and antibodies to HCV (anti-HCV) status of 284 patients (232 male, 52 female) with HCC.

    They also evaluated the gender ratio and mean age of these patients.


    The mean age of HBsAg positive patients was significantly lower than the mean age of HBsAg negative patients (52.6 ± 12.3 vs. 61.3 ± 11.2 years) (P<0.05).

    The male-to-female ratio was 4.5 : 1 for all HCC patients, 7 : 1 for HBsAg positive HCC patients, and 2.8 : 1 for anti-HCV positive HCC patients.

    In Chaiyi County in southern Taiwan, the prevalence of anti-HCV in male HCC patients was 52%, significantly greater than that of Taiwan as a whole (27.6%) (P=0.07).

    However, the prevalence of anti-HCV in male HCC patients in Taipei County in northern Taiwan was 8.7%, significantly less than that of Taiwan as a whole (P=0.043).

    Of a total of 65 Chiayi-based HCC patients, 55.4% were anti-HCV positive and 46.2% were HBsAg positive. (...)

    Mots-clés Pascal : Carcinome hépatocellulaire, Etiologie, Prévalence, Hépatite virale C, Virose, Infection, Hépatite virale B, Variation géographique, Age, Sexe, Taiwan, Asie, Epidémiologie, Homme, Appareil digestif pathologie, Foie pathologie, Tumeur maligne

    Mots-clés Pascal anglais : Hepatocellular carcinoma, Etiology, Prevalence, Viral hepatitis C, Viral disease, Infection, Viral hepatitis B, Geographical variation, Age, Sex, Taiwan, Asia, Epidemiology, Human, Digestive diseases, Hepatic disease, Malignant tumor

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0474709

    Code Inist : 002B13C01. Création : 22/03/2000.