Congress of the Asian Federation of Coloproctology. Taipei, TWN, 1997/11/13.
Although the efficacy of mass screening for colorectal carcinoma (CRC) with a fecal occult blood test has been demonstrated in several randomized trials, a mass screening approach used in countries with intermediate or low incidence of CRC might be costly.
Screening high risk people may be an alternative approach, to aid in the prevention of death from CRC.
However, the efficacy of CRC screening for high risk people in such countries is uncertain.
For this study, a multicenter design was devised to identify high risk groups without clinical symptoms related to CRC ; these subjects were identified through the study of index cases of CRC in Taiwan.
Colonoscopy, in combination with a fecal occult blood test or double-contrast barium enema, was used to screen high risk groups.
A total of 8909 subjects were invited to attend screening.
Of 8909,81 with asymptomatic CRC were detected in one-shot screening.
Markov models, in conjunction with a simulated approach, were proposed to estimate relevant parameters in relation to disease progression and to assess the effect of the interval between screenings on the efficacy of CRC screening for these high risk groups.
The estimated preclinical incidence rate was 0.00396 (95% confidence interval [CI], 0.002944-0.004985), which was 21 times that reported from a cancer registry in 1994. (...)
Mots-clés Pascal : Carcinome, Côlon, Rectum, Colonoscopie, Sang, Fèces, Lavement baryté, Dépistage, Facteur risque, Taiwan, Asie, Etude multicentrique, Homme, Tumeur maligne, Appareil digestif pathologie, Intestin pathologie, Côlon pathologie, Rectum pathologie, Endoscopie, Radiodiagnostic
Mots-clés Pascal anglais : Carcinoma, Colon, Rectum, Colonoscopy, Blood, Feces, Barium enema, Medical screening, Risk factor, Taiwan, Asia, Multicenter study, Human, Malignant tumor, Digestive diseases, Intestinal disease, Colonic disease, Rectal disease, Endoscopy, Radiodiagnosis
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0474706
Code Inist : 002B13B01. Création : 22/03/2000.