Specific inhalation challenge with wheat flour in workers with suspected baker's asthma.
The aim of this study was to evaluate the outcome of the specific inhalation challenge test (SIC) in 160 subjects with suspected baker's asthma and to assess its relation to total flour dust levels and to personal characteristics such as specific skin sensitisation, non-specific bronchial hyper-responsiveness (NSBH) and atopy.
We investigated the outcome of SIC tests performed with wheat flour in six Italian laboratories.
For each subject, data was available regarding skin sensitisation to wheat flour, NSBH, atopy, forced expiratory volume at I s (FEVI) monitoring and airborne flour dust in the challenge chamber measured by the gravimetric method (total dust in mg/m3).
The SIC test was positive for early asthma in 42 subjects (26%) and for late/dual asthma in 18 (11%). Positive outcome to SIC was significantly associated with NBSH (odds ratio, OR : 3.5,95% CI : 1.6-7.7) and skin sensitisation to wheat flour (OR : 3.1,95% CI : 1.3-7.0).
Exposure level to wheat flour was less than or equal to 10 mg/m3 in 12% of individuals, ranged between 11 and 30 mg/m3 in 43% and exceeded 30 mg/m3 in 45%. The outcome of SIC was always negative among workers not skin sensitised to wheat flour and without NSBH and atopy.
An increasing prevalence of positive SIC was observed among workers with one or more of the above-mentioned personal characteristics whose challenge exposure was greater than 10 mg/m3 (P<0.001). (...)
Mots-clés Pascal : Farine, Blé, Toxicité, Boulanger, Homme, Asthme, Exposition professionnelle, Médecine travail, Hypersensibilité, Inhalation, Particule en suspension, Essai, Appareil respiratoire pathologie, Bronchopneumopathie obstructive
Mots-clés Pascal anglais : Flour, Wheat, Toxicity, Baker, Human, Asthma, Occupational exposure, Occupational medicine, Hypersensitivity, Inhalation, Suspended particle, Test, Respiratory disease, Obstructive pulmonary disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0474328
Code Inist : 002B03L03. Création : 22/03/2000.