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  1. A hypothesis concerning deficiency of sunlight, cold temperature, and influenza epidemics associated with the onset of acute lymphoblastic leukemia in northern Finland.

    Article - En anglais

    Research to detect new factors contributing to the etiology of acute leukemia (AL) is urgently needed.

    Located between latitudes 65° and 70° north, the population in northern Finland is exposed to extreme seasonal alterations of ultraviolet-B light and temperature.

    There is also a seasonal variation of both the 25 (OH) - and 1,25 (OH) 2-D3 vitamin serum concentrations.

    In the present work, the frequencies of different types and age-groups at diagnosis of AL were compared during the dark and light months of the year, to uncover seasonality.

    Between January 1972 and December 1986,300 consecutive patients aged >= 16 years and diagnosed as having AL were enrolled.

    The observed mean monthly global solar radiation, temperature measurements, and influenza epidemics were compared with the monthly occurrence of AL.

    Both acute lymphoblastic leukemia (ALL) (p=0.006) and total AL (p=0.015) were diagnosed excessively in the dark and cold compared with light and warm period of the year.

    There was a tendency for de novo leukemia to increase also in the dark and cold, but for acute myeloid leukemia (AML) patients the excess was not significant.

    Age >= 65 was strongly associated with the dark and cold season (p=0.003).

    Significantly more ALL (p=0.005) and de novo leukemias (p=0.029) were observed during influenza epidemics than during nonepidemic periods. (...)

    Mots-clés Pascal : Leucémie lymphoblastique, Facteur risque, Epidémiologie, Rayonnement solaire, Rayonnement UV, Onde électromagnétique, Temps froid, Température, Vitamine D, Grippe, Virose, Infection, Finlande, Europe, Homme, Aigu, Hémopathie maligne, Lymphoprolifératif syndrome

    Mots-clés Pascal anglais : Acute lymphocytic leukemia, Risk factor, Epidemiology, Solar radiation, Ultraviolet radiation, Electromagnetic wave, Cold weather, Temperature, Vitamin D, Influenza, Viral disease, Infection, Finland, Europe, Human, Acute, Malignant hemopathy, Lymphoproliferative syndrome

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0467934

    Code Inist : 002B19B. Création : 22/03/2000.