Prior to possible introduction of large-scale vaccination programmes, an estimation and comparison of naturally acquired immunity against Haemophilus influenzae type b (Hib) was carried out in two populations of age-stratified infants and children (from birth to 14 years old) in Burkina-Faso (West Africa) (n=206) and France (n=206).
Hib capsular polysaccharide antibodies were detected by an ELISA method.
The difference in the percentages of minimum protective levels for the two populations were not significant (0.15 mug/ml) for newborns (0-1 month) but became significant as early as 2 to 3 months of age (p<0.01) when lower levels were found among infants from Burkina-Faso.
Subsequently, the percentages in both countries remained low until 11 months of age and showed no significant differences.
For children between 12 and 35 months, the results >=0.15 mug/ml were significantly higher in France (p<0.05).
From 36 months, the percentage of minimum seropositivity increased in Burkina-Faso, so that the difference was no longer significant.
In each country, the percentage of children with the minimum protective level varied significantly (p <= 0.05) according to age (0-47 months).
None of the children from Burkina-Faso or France had antibody levels>1.0 mug/ml before one year of age.
Thereafter, only 9.51% of French children in the 12-to 17-month age stratum and 19.2% over 4 years of age had antibody levels>1.0 mug/ml. (...)
Mots-clés Pascal : Vaccination, Haemophilus influenzae, Pasteurellaceae, Bactérie, Programme sanitaire, Immunisation, Epidémiologie, Evaluation, Etude comparative, Nourrisson, Homme, Enfant, Burkina Faso, Afrique, France, Europe
Mots-clés Pascal anglais : Vaccination, Haemophilus influenzae, Pasteurellaceae, Bacteria, Sanitary program, Immunization, Epidemiology, Evaluation, Comparative study, Infant, Human, Child, Burkina Faso, Africa, France, Europe
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0467808
Code Inist : 002B05A02. Création : 22/03/2000.