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  1. Evaluation of a long-chain polyunsaturated fatty acid supplemented formula on growth, tolerance, and plasma lipids in preterm infants up to 48 weeks postconceptional age.

    Article - En anglais


    The last trimester of pregnancy is a period of rapid accretion of long-chain polyunsaturated fatty acids, both in the central nervous system and the body as a whole.

    Human milk contains these fatty acids, whereas some preterm infant formulas do not.

    Infants fed formulas without these fatty acids have lower plasma and erythrocyte concentrations than infants fed human milk.

    Preclinical and clinical studies have demonstrated that single-cell sources (algal and fungal) of long-chain polyunsaturated fatty acids are bioavailable.

    A balanced addition of fatty acids from these oils to preterm formula results in blood fatty acid concentrations in low birth weight infants comparable to those of infants fed human milk.


    In the present study the growth, acceptance (overall incidence of discontinuation, reasons for discontinuation, overall incidence and type of individual adverse events), and plasma fatty acid concentrations were compared in three groups of infants fed a long-chain polyunsaturated fatty acid-supplemented preterm infant formula, an unsupplemented control formula, or human milk.

    The study was prospective, double-blind (formula groups only), and randomized (formula groups only).

    Two hundred eighty-eight infants were enrolled (supplemented formula group, n=77 ; control formula group, n=78 ; human milk group, n=133). (...)

    Mots-clés Pascal : Nourrisson, Homme, Poids naissance faible, Protocole thérapeutique, Acide gras polyinsaturé, Chaîne longue, Supplémentation, Lait infantile, Tolérance, Etude comparative, Effet secondaire, Analyse biochimique, Evaluation, Obstétrique, Pédiatrie, Biologie moléculaire, Nutrition

    Mots-clés Pascal anglais : Infant, Human, Low birth weight, Therapeutic protocol, Polyunsaturated fatty acid, Long chain, Supplementation, Infant formula, Tolerance, Comparative study, Secondary effect, Biochemical analysis, Evaluation, Obstetrics, Pediatrics, Molecular biology, Nutrition

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0467556

    Code Inist : 002B20G01. Création : 22/03/2000.