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  1. Influenza vaccines : Antibody responses to split virus and MF59-adjuvanted subunit virus in an adult population.

    Article - En anglais

    The humoral immune response generated by two commercial influenza vaccines was evaluated in a randomised, double-blind trial performed in the Public Department of Dolo Health District (Northeast Italy) during the winter season 1997-1998.

    Ninety-eight subjects were immunised with a split virus vaccine and ninety-six with a MF59-adjuvanted subunit virus vaccine (SU/MF59).

    The pre-and postvaccination (~30 days) antibody titres were determined by hemagglutination inhibition test (HI).

    After immunisation protective titre rates (>=1 : 40) were near 100% against virus A strain and 82.5% against B strain.

    Both vaccines caused significant rises in geometric mean antibody titres (GMTs) ; however, people who received SU/MF59 vaccine were found to develop a greater immune response compared to the group immunised with SVV.

    According to logistic regression analysis the unprotective prevaccination immune status and the use of SU/MF59 were identified as independent factors significantly increasing the response to immunisation.

    Mots-clés Pascal : Vaccination, Grippe, Virose, Infection, Anticorps, Sérologie, Réponse immune, Plasma sanguin, Epidémiologie, Evaluation, Efficacité, Adulte, Homme, Italie, Europe

    Mots-clés Pascal anglais : Vaccination, Influenza, Viral disease, Infection, Antibody, Serology, Immune response, Blood plasma, Epidemiology, Evaluation, Efficiency, Adult, Human, Italy, Europe

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0465064

    Code Inist : 002B05A02. Création : 22/03/2000.