Radiation-induced chromosomal aberrations and haematological alterations in hospital workers.
Long term exposure to low doses of ionizing radiation may affect cells and tissues and result in various adverse health effects.
The purpose of this study was to investigate whether chromosome aberrations and haematological alterations could be used as biomarkers of possible radiation injury in workers exposed to ionizing radiation.
Groups totalling 323 medical professionals handling X-ray equipment and 160 control subjects were examined for incidence of chromosome aberrations and changes in leukocyte, lymphocyte and thrombocyte counts.
The incidence of all types of chromosome aberrations was higher ir the exposed groups than in controls, yet no significant difference was found between the exposed groups.
A many-fold increase in chromosome aberration frequency in all exposed groups was not followed by a corresponding haematological depression.
This suggests that chromosome aberrations are a significantly more sensitive indicator of changes caused by low doses of ionizing radiation than haematological alterations.
Mots-clés Pascal : Rayonnement ionisant, Hématologie, Hôpital, Irradiation ionisante, Personnel sanitaire, Toxicité, Effet biologique, Dose faible, Long terme, Chronique, Exposition professionnelle, Médecine travail, Homme, Aberration chromosomique, Marqueur biologique, Numération, Cellule sanguine, Leucocyte, Hémopathie, Thrombocyte
Mots-clés Pascal anglais : Ionizing radiation, Hematology, Hospital, Ionizing irradiation, Health staff, Toxicity, Biological effect, Low dose, Long term, Chronic, Occupational exposure, Occupational medicine, Human, Chromosomal aberration, Biological marker, Numeration, Blood cell, Leukocyte, Hemopathy, Platelet
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0464965
Code Inist : 002A08F02. Création : 22/03/2000.