One of the remarkable clinical consequences of the Chernobyl accident was skin involvement, leading to extensive cutaneous fibrosis.
Apart from surgery, no established treatment is available.
A group of survivors, working in or present at the accident site on April 26,1986, and a few days thereafter, were examined, treated, and followed-up in 6-month intervals from September 1991 to November 1995.
Eight individuals were identified as suffering from excessive cutaneous fibrosis.
Skin thickness was measured with high-frequency (20 MHz) ultrasound in a clinically well-defined target skin lesion, in addition to histologic confirmation of radiation fibrosis.
Interferon gamma was scheduled for all patients on a low-dose regimen (3 x 50 mug/week s.c.). In 2 patients, interferon was discontinued after the first injection, due to withdrawal of consent.
In 6 patients, interferon was continued for 30 months, with 1 injection weekly for a further 6 months.
Treatment was discontinued in November 1994.
Four patients in the treated group and 1 of the 2 patients treated only once ( « untreated patients ») were reexamined 1 year later.
In all individuals treated for 36 months, a significant (p<0.005) reduction of radiation fibrosis could be determined, in contrast to a significant (p<0.005) increase in the 2 untreated patients.
Follow-up 1 year after discontinuation of the interferon treatment demonstrated significant (p<0.005) recurrence of fibrosis. (...)
Mots-clés Pascal : Radiolésion, Pollution radioactive, Homme, Fibrose, Complication, Efficacité traitement, Interféron gamma, Immunothérapie, Evaluation, Tchernobyl
Mots-clés Pascal anglais : Radiation injury, Radioactive pollution, Human, Fibrosis, Complication, Treatment efficiency, Gamma interferon, Immunotherapy, Evaluation
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0460122
Code Inist : 002B02W. Création : 22/03/2000.