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  1. Interferon gamma in survivors of the chernobyl power plant accident : New therapeutic option for radiation-induced fibrosis.

    Article - En anglais


    One of the remarkable clinical consequences of the Chernobyl accident was skin involvement, leading to extensive cutaneous fibrosis.

    Apart from surgery, no established treatment is available.


    A group of survivors, working in or present at the accident site on April 26,1986, and a few days thereafter, were examined, treated, and followed-up in 6-month intervals from September 1991 to November 1995.

    Eight individuals were identified as suffering from excessive cutaneous fibrosis.

    Skin thickness was measured with high-frequency (20 MHz) ultrasound in a clinically well-defined target skin lesion, in addition to histologic confirmation of radiation fibrosis.

    Interferon gamma was scheduled for all patients on a low-dose regimen (3 x 50 mug/week s.c.). In 2 patients, interferon was discontinued after the first injection, due to withdrawal of consent.

    In 6 patients, interferon was continued for 30 months, with 1 injection weekly for a further 6 months.

    Treatment was discontinued in November 1994.

    Four patients in the treated group and 1 of the 2 patients treated only once ( « untreated patients ») were reexamined 1 year later.


    In all individuals treated for 36 months, a significant (p<0.005) reduction of radiation fibrosis could be determined, in contrast to a significant (p<0.005) increase in the 2 untreated patients.

    Follow-up 1 year after discontinuation of the interferon treatment demonstrated significant (p<0.005) recurrence of fibrosis. (...)

    Mots-clés Pascal : Radiolésion, Pollution radioactive, Homme, Fibrose, Complication, Efficacité traitement, Interféron gamma, Immunothérapie, Evaluation, Tchernobyl

    Mots-clés Pascal anglais : Radiation injury, Radioactive pollution, Human, Fibrosis, Complication, Treatment efficiency, Gamma interferon, Immunotherapy, Evaluation

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0460122

    Code Inist : 002B02W. Création : 22/03/2000.