The relationship between celiac disease and many autoimmune disorders has been explained by the sharing of a common genetic factor.
In a multicenter national study, we examined the relationship between the prevalence of autoimmune disorders in celiac disease and the duration of exposure to gluten.
Over a 6-month period, 909 patients with celiac disease (group A ; mean age, 16.1 ± 3.8 years ; grouped according to age at diagnosis into three subgroups [group A1,<2 years ; group A2,2-10 years ; and group A3,>10 years]), 1268 healthy controls (group B ; mean age, 20.8 ± 4.5 years), and 163 patients with Crohn's disease (group C ; mean age, 28.8<10 years) were evaluated for the presence of autoimmune disorders.
Prevalence of autoimmune disorders in group A was significantly higher than in group B (14% vs. 2.8% ; P<0.000001) but not higher than in group C (12.9%). Prevalence of autoimmune disorders in celiac disease increased with increasing age at diagnosis : 5.1% in group A1,17% in group A2, and 23.6% in group A3 (P=0.000001).
In group A3, the prevalence of autoimmune disorders was significantly higher than in group C. In a logistic regression model, age at diagnosis was the only significant predictor variable of the odds of developing an autoimmune disorder (r=0.3 ; P<0.000001).
Our data show for the first time that the prevalence of autoimmune disorders in celiac disease is related to the duration of exposure to gluten.
Mots-clés Pascal : Coeliaque maladie, Complication, Maladie autoimmune, Facteur risque, Temps exposition, Gluten, Epidémiologie, Homme, Appareil digestif pathologie, Intestin pathologie, Malabsorption intestinale, Immunopathologie, Nutrition
Mots-clés Pascal anglais : Coeliac disease, Complication, Autoimmune disease, Risk factor, Exposure time, Gluten, Epidemiology, Human, Digestive diseases, Intestinal disease, Intestinal malabsorption, Immunopathology, Nutrition
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0459401
Code Inist : 002B13B03. Création : 22/03/2000.