It has been suggested that oestrogen replacement therapy is associated with risk of epithelial ovarian cancer of the endometrioid type.
Using data from an Australian population-based case-control study, the relation between unopposed oestrogen replacement therapy and epithelial ovarian cancer, both overall and according to histological type, was examined.
A total of 793 eligible incident cases of epithelial ovarian cancer diagnosed from 1990 to 1993 among women living in Queensland, New South Wales and Victoria were identified.
These were compared with 855 eligible female controls selected at random from the electoral roll, stratified by age and geographic region.
Trained interviewers administered standard questionnaires to obtain detailed reproductive and contraceptive histories, as well as details about hormone replacement therapy and pelvic operations.
No clear associations were observed between use of hormone replacement therapy overall and risk of ovarian cancer.
Unopposed oestrogen replacement therapy was, however, associated with a significant increase in risk of endometrioid or clear cell epithelial ovarian tumours (odds ratio (OR) 2.56 ; 95% confidence interval (Cl) 1.32-4.94).
In addition, the risk associated with oestrogen replacement therapy was much larger in women with an intact genital tract (OR 3.00 ; 95% CI 1.54-5.85) than in those with a history of either hysterectomy or tubal ligation. (...)
Mots-clés Pascal : Carcinome, Ovaire, Facteur risque, Epidémiologie, Traitement substitutif, Hormone stéroïde, Oestrogène, Toxicité, Ligature, Trompe, Hystérectomie, Etude cas témoin, Australie, Océanie, Homme, Tumeur maligne, Appareil génital femelle pathologie, Ovaire pathologie, Chirurgie
Mots-clés Pascal anglais : Carcinoma, Ovary, Risk factor, Epidemiology, Replacement therapy, Steroid hormone, Estrogen, Toxicity, Ligature, Proboscis, Hysterectomy, Case control study, Australia, Oceania, Human, Malignant tumor, Female genital diseases, Ovarian diseases, Surgery
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0458936
Code Inist : 002B20C02. Création : 22/03/2000.