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  1. Pragmatic randomised controlled trials in psychiatry.

    Article - En anglais

    Background Randomised controlled trials (RCTs) are the most important method of evaluating new treatments and treatment policies.

    Despite this, there are relatively few large pragmatic RCTs in psychiatry.

    Aims To explore the main advantages of large pragmatic RCTs and the obstacles to performing them in psychiatry.

    Method A narrative review of literature on pragmatic RCTs with examples drawn from psychiatry and other medical specialities.

    Results Obstacles to performing pragmatic RCTs in psychiatry include the complexity of psychiatric interventions, the complexity of outcomes used in psychiatry and the difficulties of blinding subjects and investigators to some psychiatric interventions.

    Conclusions Researchers need to frame questions in a form that is relevant to clinicians and to convince clinicians to cooperate in simple large pragmatic trials.

    Declaration of interest Some ofthis work was funded by the Department of Health.

    Mots-clés Pascal : Evaluation, Traitement, Trouble psychiatrique, Efficacité traitement, Politique sanitaire, Méthodologie, Essai thérapeutique contrôlé, Randomisation, Pragmatique, Santé mentale, Environnement social, Grande Bretagne, Royaume Uni, Europe, Analyse coût, Economie santé, Article synthèse, Homme

    Mots-clés Pascal anglais : Evaluation, Treatment, Mental disorder, Treatment efficiency, Health policy, Methodology, Controlled therapeutic trial, Randomization, Pragmatics, Mental health, Social environment, Great Britain, United Kingdom, Europe, Cost analysis, Health economy, Review, Human

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0457670

    Code Inist : 002B18B04. Création : 22/03/2000.