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  1. A randomized double-blind placebo-controlled trial evaluating the cost-effectiveness of droperidol as a sedative premedication for EUS.

    Article - En anglais

    Background 

    Droperidol Is a neuroleptic agent with anti-emetic properties that produces mild sedation, reduced anxlety, and a state of mental detachment and indifference to one's surroundings.

    Routine premedication with droperidol has been shown to improve sedation during esopha-gogastroduodenoscopy and endoscopic retrograde cholangiopancreatography.

    The purpose of this randomized double-blind placebo-controlled study was to determine whether premedication with droperidol Improves sedation during routine upper endoscopic ultrasound (EUS) in a cost-effective manner.

    Methods 

    One hundred consecutive patients referred for EUS were randomly assigned to receive either 2.5 mg or 5 mg of droperidol or placebo before the procedure.

    After EUS, the physiclan, nurse, and recovered patient scored various parameters of procedural sedation.

    Results 

    In the group receiving 5 mg of droperidol there was significantly less gagging at intubation, less retching during the procedure, better patient cooperation, less need for physical restraint, and improved nurses'and physiclan's Impression of sedation.

    Significantly less meperidine and less midazolam were required for sedation, making medication costs significantly lower in the group receiving 5 mg droperidol.

    Conclusions 

    A 5 mg dose of droperidol given as premedication for routine upper EUS improves sedation during the procedure while significantly decreasing the overall cost of sedation.

    Mots-clés Pascal : Imagerie ultrasonore, Voie abord, Laparoscopie, Dropéridol, Prémédication, Randomisation, Analyse coût efficacité, Etude double insu, Placebo, Sédation, Evaluation, Homme, Butyrophénone dérivé, Imagerie médicale, Radiodiagnostic, Neuroleptique, Tranquillisant, Psychotrope, Economie santé

    Mots-clés Pascal anglais : Ultrasound imaging, Surgical approach, Laparoscopy, Droperidol, Premedication, Randomization, Cost efficiency analysis, Double blind study, Placebo, Sedation, Evaluation, Human, Butyrophenone derivatives, Medical imagery, Radiodiagnosis, Neuroleptic, Tranquillizer, Psychotropic, Health economy

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0455182

    Code Inist : 002B02B03. Création : 22/03/2000.