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  1. The physical activity for total health (PATH) study : rationale and design.

    Article - En anglais


    Physical activity has been associated with a decreased risk for breast cancer.

    Mechanisms for this association may involve hormonal pathways.

    The Physical Activity for Total Health study is testing the effect of a 1-yr moderate intensity physical activity intervention on the endogenous sex hormone profile of postmenopausal women in a randomized controlled study.


    Women (N=168) who are aged 55-75 yr, not using sex hormones, sedentary, nonsmokers, have no endocrine-related disease or cancer, and with body mass index of 25.0 or greater, are eligible.

    Women are recruited through mass mailings and media advertising and are randomized to either a 1-yr moderate intensity aerobic and strength training exercise program (monitored group exercise sessions plus home exercise) or a control program (stretching classes).


    Serum hormones to be assayed at baseline and at the end of the study include : total estrone, total estradiol, free estradiol, percent bioavailable estradiol, estrone sulfate, sex hormone binding globulin, albumin, testosterone, free testosterone, androstenedione, dehydroepiandrosterone, dehydroepiandrosterone sulfate, insulin, glucose, and triglycerides. (...)

    Mots-clés Pascal : Postménopause, Exercice physique, Mode de vie, Prévention, Oestrogène, Androgène, Essai clinique, Tumeur maligne, Glande mammaire, Hormone stéroïde sexuelle, Glande mammaire pathologie, Homme, Femelle

    Mots-clés Pascal anglais : Postmenopause, Physical exercise, Life style, Prevention, Estrogen, Androgen, Clinical trial, Malignant tumor, Mammary gland, Sex steroid hormone, Mammary gland diseases, Human, Female

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0454641

    Code Inist : 002B04B. Création : 22/03/2000.