The association of baseline fatty acid composition in plasma cholesterol esters with 6-year incidence of hypertension was examined in middle-aged Minneapolis participants of the Atherosclerosis Risk in Communities (ARIC) Study (1987-1995).
Compared with those who were never hypertensive (n=1,975), incident hypertensives (n=413) had statistically significantly higher baseline levels of palmitic (16 : 0) and palmitoleic (16 : 1n7) acids but lower levels of linoleic (18 : 2n6) acid and the polyunsaturated/saturated fatty acids ratio (P/S ratio).
Among polyunsaturated fatty acids, levels of dihomo-gamma-linolenic (20 : 3n6) and arachidonic (20 : 4n6) acids were statistically significantly higher in incident hypertensives, compared with normotensives.
After adjustment for age, sex, body mass index, waist/hip ratio, smoking status, ethanol intake, education level, physical activity, and baseline systolic blood pressure in separate models, the odds ratio estimates of incident hypertension for an interquartile increment of a fatty acid in cholesterol esters were 1.26 (95% confidence interval (Cl) : 1.05,1.51) for 16 : 0,1.11 (95% Cl : 0.96,1.28) for 16 : 1n7,1.01 (95% Cl : 0.85,1.21) for 20 : 3n6,1.14 (95% Cl : 1.03,1.27) for 20 : 5n3,0.81 (95% CI : 0.68,0.96) for 18 : 2n6, and 0.83 (95% Cl : 0.70,0.99) for the P/S ratio. (...)
Mots-clés Pascal : Hypertension artérielle, Acide gras saturé, Acide gras polyinsaturé, Plasma sanguin, Composition, Ratio, Epidémiologie, Facteur risque, Incidence, Adulte, Homme, Etats Unis, Amérique du Nord, Amérique, Appareil circulatoire pathologie, Acide gras
Mots-clés Pascal anglais : Hypertension, Saturated fatty acid, Polyunsaturated fatty acid, Blood plasma, Composition, Ratio, Epidemiology, Risk factor, Incidence, Adult, Human, United States, North America, America, Cardiovascular disease, Fatty acids
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0451645
Code Inist : 002B12B05B. Création : 22/03/2000.