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  1. Fulltext. Plasma fatty acid composition and 6-year incidence of hypertension in middle-aged adults : The Atherosclerosis Risk in Communities (ARIC) Study.

    Article - En anglais


    The association of baseline fatty acid composition in plasma cholesterol esters with 6-year incidence of hypertension was examined in middle-aged Minneapolis participants of the Atherosclerosis Risk in Communities (ARIC) Study (1987-1995).

    Compared with those who were never hypertensive (n=1,975), incident hypertensives (n=413) had statistically significantly higher baseline levels of palmitic (16 : 0) and palmitoleic (16 : 1n7) acids but lower levels of linoleic (18 : 2n6) acid and the polyunsaturated/saturated fatty acids ratio (P/S ratio).

    Among polyunsaturated fatty acids, levels of dihomo-gamma-linolenic (20 : 3n6) and arachidonic (20 : 4n6) acids were statistically significantly higher in incident hypertensives, compared with normotensives.

    After adjustment for age, sex, body mass index, waist/hip ratio, smoking status, ethanol intake, education level, physical activity, and baseline systolic blood pressure in separate models, the odds ratio estimates of incident hypertension for an interquartile increment of a fatty acid in cholesterol esters were 1.26 (95% confidence interval (Cl) : 1.05,1.51) for 16 : 0,1.11 (95% Cl : 0.96,1.28) for 16 : 1n7,1.01 (95% Cl : 0.85,1.21) for 20 : 3n6,1.14 (95% Cl : 1.03,1.27) for 20 : 5n3,0.81 (95% CI : 0.68,0.96) for 18 : 2n6, and 0.83 (95% Cl : 0.70,0.99) for the P/S ratio. (...)

    Mots-clés Pascal : Hypertension artérielle, Acide gras saturé, Acide gras polyinsaturé, Plasma sanguin, Composition, Ratio, Epidémiologie, Facteur risque, Incidence, Adulte, Homme, Etats Unis, Amérique du Nord, Amérique, Appareil circulatoire pathologie, Acide gras

    Mots-clés Pascal anglais : Hypertension, Saturated fatty acid, Polyunsaturated fatty acid, Blood plasma, Composition, Ratio, Epidemiology, Risk factor, Incidence, Adult, Human, United States, North America, America, Cardiovascular disease, Fatty acids

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0451645

    Code Inist : 002B12B05B. Création : 22/03/2000.