Background Primary biliary cirrhosis (PBC) is a chronic cholestatic liver disease of unknown aetiology.
A number of drugs have been used in its treatment, but only ursodeoxycholic acid (UDCA) has been shown to improve survival.
Our aims were to determine the current prescribing habits in PBC of all practising gastroenterologists in the UK.
Methods A postal questionnaire was sent to 454 gastroenterologists in 1996, followed by a second questionnaire a month later to the non-responders.
Results Of 454 doctors sent questionnaires, 379 (83%) replied.
Of these, 58 were excluded from further analysis as they were not practising gastroenterologists.
There are an estimated 4337 patients with PBC being seen by gastroenterologists in hospitals.
Of these, only 1376 (32%) are being seen in liver units.
Ninety-one per cent of gastroenterologists look after patients with PBC (median 10 patients, range 1-500).
Ninety-five per cent of gastroenterologists prescribe UDCA but there is a large dose range (median 11.5 mg/kg/day, range 1.5-23.1).
Of these, 93% also prescribe cholestyramine.
Only 45 (14%) gastroenterologists prescribed other treatments for PBC (13 colchicine, 24 steroids, nine penicillamine, 13 immunosuppressants).
Only 53 (17%) treat the symptoms/complications of PBC (37 fat-soluble vitamins, 15 calcium, six bisphosphonates, one hormone replacement therapy, 10 antihistamines, 10 rifampicin). (...)
Mots-clés Pascal : Cirrhose biliaire, Primitif, Chimiothérapie, Acide ursodéoxycholique, Prescription médicale, Questionnaire, Enquête opinion, Homme, Appareil digestif pathologie, Foie pathologie, Voie biliaire pathologie, Immunopathologie, Maladie autoimmune
Mots-clés Pascal anglais : Biliary cirrhosis, Primitive, Chemotherapy, Ursodeoxycholic acid, Medical prescription, Questionnaire, Opinion inquiry, Human, Digestive diseases, Hepatic disease, Biliary tract disease, Immunopathology, Autoimmune disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0451299
Code Inist : 002B02H. Création : 22/03/2000.