Traduction en anglais : Renal phenotypes of essential hypertension in Caribbean women.
The characterisation of phenotypes of patients with essential hypertension (EH) is an important pre-requisite for genetic research.
The present study compares cli-nical and renal function parameters in 2 groups of patients from different origins.
Out of a cohort of essential hypertensives disclosed on routine work medical examinations, 21 caucasian (CC) women were paired with 21 Caribbean (CB) women.
In the 2 groups we recorded family history of hypertension (FHH), duration of hypertension, BMI, salt intake based on 24h urinary sodium excretion, microalbuminuria, and blood pressure (BP).
Glomerular filtration rate (GFR) and renal plasma flow (RPF) were measured with inulin and para-amino-hippuric acid clearances.
Plasma active renin (AR) and aldosterone (Aldo) levels were measured by immuno-assays.
White coat (WC) effect was assessed on the difference between BP values measured on medical visits and by the nurses on clearance measurements.
Anova and t-test were used for analysis, statistical significance was assumed for p<0.05.
Casual BP values were 150/94 mmHg in CB and 153/95 mmHg in CC.
There were no significant differences on BMI (CB 30.6 kg/m2 vs CC 27.1 kg/m2), AR (CB 6.6 pg/mL vs CC 8.7 pg/mL) and Aldo (CB 195.1 1 pmol/L vs CC 202.8 pmol/L) provided an equivalent dietary salt intake (CB 11.2 g/d vs CC 10.7 g/d), Mother FHH was found predominantly in CB women (60% vs 30% in CC. p<0. (...)
Mots-clés Pascal : Hypertension artérielle, Femelle, Homme, Antilles, Amérique Centrale, Amérique, Epidémiologie, Phénotype, Fonction rénale, Appareil circulatoire pathologie
Mots-clés Pascal anglais : Hypertension, Female, Human, West Indies, Central America, America, Epidemiology, Phenotype, Renal function, Cardiovascular disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0451282
Code Inist : 002B12B05B. Création : 22/03/2000.