Colorectal cancer in hereditary breast cancer kindreds.
Meeting of The American Society of Colon and Rectal Surgeons. San Antonio, TX, USA, 1998/05/02.
This study compared characteristics of colorectal cancer between families with dominant breast cancer inheritance and the general population.
The cumulative incidence of colorectal cancer was also studied in genetically determined breast cancer syndrome subjects with BRCA1 and BRCA2 mutations and compared with the general population.
Subjects included 42 patients with colorectal cancer from 32 clinically determined hereditary breast cancer kindreds based on the autosomal dominant inheritance of breast cancers and early age of onset.
The general population colorectal cancer cohort was composed of 755 patients from a tumor registry.
Lifetime risk of colorectal cancer was determined in 164 BRCA1 and 88 BRCA2 gene mutation carriers and compared with the general population.
Mean age of colorectal cancer onset, anatomic site distribution, histologic stage at presentation, and five year stage-stratified survival rates were compared between clinically determined hereditary breast cancer family members and the general population.
The lifetime risk of colorectal cancer in male BRCA1 and BRCA2 mutation carriers was 5.6 percent, which was not different from 6 percent in males from the general population.
Likewise, the lifetime colorectal cancer risk in female BRCA1 and BRCA2 mutation carriers was 3.2 percent, which was not different from 5.9 percent in females from the general population. (...)
Mots-clés Pascal : Tumeur maligne, Glande mammaire, Incidence, Côlon, Rectum, Association morbide, Descendance, Epidémiologie, Homme, Glande mammaire pathologie, Appareil digestif pathologie, Côlon pathologie, Rectum pathologie
Mots-clés Pascal anglais : Malignant tumor, Mammary gland, Incidence, Colon, Rectum, Concomitant disease, Progeny, Epidemiology, Human, Mammary gland diseases, Digestive diseases, Colonic disease, Rectal disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0450532
Code Inist : 002B13B01. Création : 22/03/2000.