The authors investigated whether two objective allergy markers, peripheral blood eosinophilia and skin tests for common aeroallergens, were associated with cardiovascular death.
Of 5,382 subjects in the Vlagtwedde-Vlaardingen Study (the Netherlands) with data on allergy markers in 1965-1972,507 subjects died from cardiovascular disease during 30 years of follow-up.
Subjects with eosinophilia had an increased risk of cardiovascular death (relative risk (RR)=1.7 ; 95% confidence interval (Cl) : 1.4,2.2), including ischemic heart disease death (RR=1.6 ; 95% Cl : 1.2,2.2) and cerebrovascular death (RR=2.3 ; 95% Cl : 1.4,3.8), independent of major risk factors.
This association was limited to subjects with a percentage of the predicted forced expiratory volume in 1 second (FEV1% predicted) of<100%. Positive skin tests were associated with a significantly reduced cardiovascular mortality in subjects with normal lung function and weight who did not smoke (RR=0.15 ; 95% Cl : 0.05,0.46).
Conversely, when subjects with positive skin tests had a body mass index of >=25 kg/m2, had an FEV1% predicted of<80%, or smoked, they had an increased risk for cardiovascular mortality.
These results were not restricted to asthmatics.
Our data suggest a possible link between eosinophilia and positive skin tests and cardiovascular mortality, especially in combination with other risk factors associated with its mortality.
Mots-clés Pascal : Appareil circulatoire pathologie, Mortalité, Allergène, Eosinophilie, Sang, Test cutané, Asthme, Allergie, Epidémiologie, Facteur risque, Homme, Etude cohorte, Pays Bas, Europe, Appareil respiratoire pathologie, Bronchopneumopathie obstructive, Immunopathologie
Mots-clés Pascal anglais : Cardiovascular disease, Mortality, Allergen, Eosinophilia, Blood, Skin test, Asthma, Allergy, Epidemiology, Risk factor, Human, Cohort study, Netherlands, Europe, Respiratory disease, Obstructive pulmonary disease, Immunopathology
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0450308
Code Inist : 002B12B06. Création : 22/03/2000.