The authors examined the relation of constitutional factors and sun exposure to risk of basal cell carcinoma of the skin (BCC) in a prospective cohort of 44,591 predominantly Caucasian US male health professionals, 40-75 years of age and free of cancer at enrollment in 1986.
During 8 years of follow-up, 3,273 cases of self-reported BCC were documented.
The following variables were each associated with an elevated risk of BCC :
having red hair ;
green, hazel, or blue eyes ;
a tendency to sunburn ;
and north European ancestry.
The lifetime number of blistering sunburns was also positively associated with BCC risk (p trend<0.0001).
Compared with men who as teenagers had been outside less than once a week, men who had been outside weekly (relative risk (RR)=1.30 ; 95% confidence interval (Cl) : 1.14,1.47) and daily (RR=1.42 ; 95% Cl : 1.24,1.63) had an elevated risk of BCC.
Living in a region of residence with high solar radiation as an adult was also associated with an increased risk of BCC (RR=1.48 ; 95% Cl : 1.36,1.60), whereas living in such a region only in childhood did not increase BCC risk.
These results confirm the role of constitutional factors and suggest that adult sun exposure increases BCC risk.
Mots-clés Pascal : Carcinome basocellulaire, Soleil, Exposition, Tabagisme, Epidémiologie, Facteur risque, Homme, Mâle, Etats Unis, Amérique du Nord, Amérique, Caucasoïde, Prospective, Peau pathologie, Tumeur maligne
Mots-clés Pascal anglais : Basal cell carcinoma, Sun, Exposure, Tobacco smoking, Epidemiology, Risk factor, Human, Male, United States, North America, America, Caucasoid, Prospective, Skin disease, Malignant tumor
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0450307
Code Inist : 002B08A. Création : 22/03/2000.