Objectives-To evaluate the risk of cancer and other diseases among workers engaged in aircraft manufacturing and potentially exposed to compounds containing chromate, trichloroethylene (TCE), perchloroethylene (PCE), and mixed solvents.
Methods-A retrospective cohort mortality study was conducted of workers employed for at least 1 year at a large aircraft manufacturing facility in California on or after 1 January 1960.
The mortality experience of these workers was determined by examination of national, state, and company records to the end of 1996.
Standardised mortality ratios (SMRs) were evaluated comparing the observed numbers of deaths among workers with those expected in the general population adjusting for age, sex, race, and calendar year.
The SMRs for 40 cause of death categories were computed for the total cohort and for subgroups defined by sex, race, position in the factory, work duration, year of first employment, latency, and broad occupational groups.
Factory job titles were classified as to likely use of chemicals, and internal Poisson regression analyses were used to compute mortality risk ratios for categories of years of exposure to chromate, TCE, PCE, and mixed solvents, with unexposed factory workers serving as referents.
The study cohort comprised 77 965 workers who accrued nearly 1.9 million person-years of follow up (mean 24.2 years). (...)
Mots-clés Pascal : Solvant organique, Toxicité, Industrie aéronautique, Exposition professionnelle, Médecine travail, Epidémiologie, Homme, Mortalité, Chromate, Ethylène(trichloro), Ethylène(tétrachloro), Californie, Etats Unis, Amérique du Nord, Amérique
Mots-clés Pascal anglais : Organic solvent, Toxicity, Aeronautic industry, Occupational exposure, Occupational medicine, Epidemiology, Human, Mortality, Chromates, Ethylene(trichloro), Ethylene(tetrachloro), California, United States, North America, America
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0449621
Code Inist : 002B03L04. Création : 22/03/2000.