Asbestosis and small cell lung cancer in a clutch refabricator.
Objectives-To present a case of asbestosis and small cell lung cancer caused by asbestos in a clutch refabricator.
Methods-Exposed surfaces of used clutches similar to those refabricated in the worker's workplace were rinsed, and the filtrate analysed by analytical transmission electron microscopy.
Tissue samples were also analysed by this technique.
Numerous chrysotile fibres of respirable dimensions and sufficient length to form ferruginous bodies (FBs) were detected from rinsed filtrates of the clutch.
Bronchoalveolar lavage fluid contained many FBs, characteristic of asbestos bodies.
Necropsy lung tissue showed grade 4 asbestosis and a small cell carcinoma in the right pulmonary hilum.
Tissue analysis by light and analytical electron microscopy showed tissue burdens of coated and uncoated asbestos fibres greatly exceeding reported environmental concentrations (3810 FBs/g dry weight and 2 080 000 structures >=0.5 mum/g dry weight respectively). 72% Of the cores were identified as chrysotile.
Conclusions-Clutch refabrication may lead to exposure to asbestos of sufficient magnitude to cause asbestosis and lung cancer.
Mots-clés Pascal : Amiante, Chrysotile, Toxicité, Asbestose, Tumeur maligne, Bronchopulmonaire, Carcinome petite cellule, Homme, Embrayage, Garage commercial, Exposition professionnelle, Médecine travail, Automobile, Etude cas, Appareil respiratoire pathologie, Pneumoconiose, Maladie professionnelle, Poumon pathologie, Bronche pathologie, Mécanicien
Mots-clés Pascal anglais : Asbestos, Toxicity, Asbestosis, Malignant tumor, Bronchopulmonary, Small cell carcinoma, Human, Clutch, Commercial garage, Occupational exposure, Occupational medicine, Motor car, Case study, Respiratory disease, Pneumoconiosis, Occupational disease, Lung disease, Bronchus disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0449418
Code Inist : 002B03L03. Création : 22/03/2000.