Mooren ulcer in South India : Serology and clinical risk factors.
To investigate the rate of undiagnosed rheumatologic diseases and hepatitis C infection among patients with the clinical diagnosis of Mooren ulcer seen at Aravind Eye Hospital, Madurai, South India.
Twenty-one patients with the clinical diagnosis of Mooren ulcer and 44 control patients underwent a complete ophthalmic history and examination, as well as serologic testing for antinuclear antibodies, rheumatoid factor, antineutrophil cytoplasmic antibodies, herpes simplex virus 1 antibodies, and hepatitis C virus antibodies.
There were no statistically significant differences in the rates of seropositivity for antinuclear antibodies, rheumatoid factor, antineutrophil cytoplasmic antibodies, herpes simplex virus 1 antibodies, and hepatitis C virus antibodies between patients with Mooren ulcer and control patients.
Two patients with Mooren ulcer and four control patients were found to have a rheumatoid factor titer of greater than 1 : 20.
One of the control patients, but none of the patients with Mooren ulcer, was found to have serologic evidence of hepatitis C infection.
A history of corneal trauma, surgery, or infection was reported by 68% of patients with Mooren ulcer, compared with 20% of control patients (P<. 001).
Among patients with Mooren ulcer, bilateral disease occurred in 37% of patients, visual acuity was reduced to light perception in 15% of eyes, and perforation occurred in 19% of eyes. (...)
Mots-clés Pascal : Ulcère Mooren, Rhumatisme inflammatoire, Hépatite virale C, Virose, Infection, Association, Sérologie, Exploration clinique, Diagnostic, Inde, Asie, Sud, Homme, Oeil pathologie, Kératopathie, Système ostéoarticulaire pathologie, Appareil digestif pathologie, Foie pathologie
Mots-clés Pascal anglais : Mooren ulcer, Inflammatory joint disease, Viral hepatitis C, Viral disease, Infection, Association, Serology, Clinical investigation, Diagnosis, India, Asia, South, Human, Eye disease, Keratopathy, Diseases of the osteoarticular system, Digestive diseases, Hepatic disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0445798
Code Inist : 002B09E. Création : 22/03/2000.