To estimate the genetic influence on the occurrence of radiologic osteoarthritis (ROA) in the knees, hips, and hands and disc degeneration of the spine in the general population.
A random sample of 1,583 individuals was drawn to estimate the prevalence of ROA and disc degeneration in the general population.
Of 118 probands with multiple affected joint sites who were derived from this sample, we were able to recruit 257 siblings.
The variance of ROA and disc degeneration within sibling pairs was compared with the variance between sibling pairs.
Heritability estimates for ROA in the knees, hips, and hands and for disc degeneration of the spine were calculated.
OA was defined according to radiologic criteria, using the Kellgren/Lawrence grading system.
We observed that hand ROA and disc degeneration of the spine were statistically significantly more frequent in siblings than in the random sample, whereas the prevalence of knee and of hip ROA was similar and lower, respectively.
Heritability estimates for hand ROA and disc degeneration were statistically significant, P=0.56 (95% confidence interval [95% CI] 0.34-0.76) and P=0.75 (95% CI 0.30-1.00), respectively.
For knee and hip ROA, no evidence of a genetic effect in the general population was found.
Finally, the heritability estimate for a score that summed the number of joints affected in the knees, hips, hands, and spine was 0.78 (95% CI 0.52-0.98). (...)
Mots-clés Pascal : Arthrose, Pathogénie, Héritabilité, Radiographie, Evaluation, Prévalence, Epidémiologie, Génétique, Homme, Système ostéoarticulaire pathologie, Arthropathie, Maladie dégénérative, Radiodiagnostic
Mots-clés Pascal anglais : Osteoarthritis, Pathogenesis, Heritability, Radiography, Evaluation, Prevalence, Epidemiology, Genetics, Human, Diseases of the osteoarticular system, Arthropathy, Degenerative disease, Radiodiagnosis
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0444567
Code Inist : 002B15E. Création : 22/03/2000.