The TT virus (TTV), a new DNA virus found in Japan from a patient with post-transfusion hepatitis non-A-non-G, is frequently positive in the sera of patients with liver disease.
It is not established whether this virus causes liver damage.
We studied the frequency of superinfection of this virus and hepatitis C virus (HCV) known to be endemic among haemodialysis patients, and the possible deleterious effect of TTV on HCV-induced chronic liver disease.
We used primers from a conservative region in the TTV genome (Okamoto, 1998) to detect TTV.
Sera from 163 dialysis patients positive for anti-HCV and 77 dialysis patients negative for anti-HCV (control) were tested.
TT Virus positivity was 35% among HCV antibody (anti-HCV) - positive patients and 45.4% among anti-HCV-negative patients.
TT Virus positivity was unrelated to the length of haemodialysis or amounts of blood the patients had received in the past.
More anti-HCV-positive patients had a history of transfusion, but TTV positivity was not as closely associated with transfusion as anti-HCV positivity.
The severity of chronic liver disease was estimated from peak serum alanine aminotransferase levels in the preceding 6 months.
Among anti-HCV positives, TTV-positive patients tended to have less active disease ; at least there was no indication that TTV superinfection aggravated chronic hepatitic C in long-term dialysis patients. (...)
Mots-clés Pascal : Hémodialyse, Chronique, Dépistage, Hépatite virale C, Virose, Infection, Aggravation, Prévalence, Transmission, Contamination, Homme, Epuration extrarénale, Appareil digestif pathologie, Foie pathologie, TT virus
Mots-clés Pascal anglais : Hemodialysis, Chronic, Medical screening, Viral hepatitis C, Viral disease, Infection, Aggravation, Prevalence, Transmission, Contamination, Human, Extrarenal dialysis, Digestive diseases, Hepatic disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0444384
Code Inist : 002B05C02G. Création : 22/03/2000.