The effect of eradication therapy on histological changes in the gastric mucosa in patients with non-ulcer dyspepsia and Helicobacter pylori infection. Prospective randomized intervention study.
Eradication therapy results in the control of gastritis.
Little is known about its influence on changes in the topographic distribution and regression of specific mucosal alterations in patients with dyspepsia.
Our previous study has shown the complex pathological changes in the cardia, corpus and antrum in patients with Helicobacter pylori (H. pylori) infection and NUD.
To determine the effect of eradication therapy on the development of histological changes in the lower esophagus, cardia, corpus and antrum in patients with nonulcerous dyspepsia, 3 and 6 months after therapy.
Two hundred and fifty-one consecutive patients with dyspepsia (the presence of ulcer and stomach malignancy was ruled out) and H. pylori infection were followed up in a prospective study.
Every patient underwent endoscopic examination with eight biopsies taken (antrum, corpus, cardia and lower esophagus) before, and 3 and 6 months after eradication therapy (Pantoprazole 40mg daily, Amoxycilline 1000mg b.i.d., Clarithromycine 500mg b.i.d.). The biopsies were stained by (H & E) and Giemsa's staining modified for H. pylori detection.
The inflammation, its activity, H. pylori and other mucosal alterations were investigated semi-quantitatively and assessed according to the Sydney system.
In the cardia, corpus and antrum, significant decrease in chronic inflammation, and H. pylori activity (p<0.001) was found. (...)
Mots-clés Pascal : Dyspepsie, Association, Infection, Helicobacter pylori, Spirillaceae, Spirillales, Bactérie, Randomisation, Traitement, Eradication, Topographie, Muqueuse, Histologie, Etude comparative, Homme, Efficacité, République tchèque, Europe, Appareil digestif pathologie, Bactériose, Anatomopathologie
Mots-clés Pascal anglais : Dyspepsia, Association, Infection, Helicobacter pylori, Spirillaceae, Spirillales, Bacteria, Randomization, Treatment, Eradication, Topography, Mucosa, Histology, Comparative study, Human, Efficiency, Czech Republic, Europe, Digestive diseases, Bacteriosis, Pathology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0444279
Code Inist : 002B05B02F. Création : 22/03/2000.