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  1. Antimutagenic activity of isoflavones from soybean seeds (Glycine max Merrill).

    Article - En anglais

    Two isoflavones, daidzein (1) and genistein (2), were isolated from soybean hypocotyls.

    Daidzein and genistein showed a suppressive effect on umu gene expression of the SOS response in Salmonella typhimurium TA1535/pSK1002 against the mutagen 3-amino-1,4-dimethyl-5H-pyrido[4,3b]indole (Trp-P-1), which requires liver metabolizing enzymes.

    Compound 1 suppressed 73% of the SOS-inducing activity at concentrations<0.74 mumol/mL, and the ID50 value was 0.37 mumol/mL.

    Compound 2 suppressed 95% of the SOS-inducing activity at concentrations<0.74 mumol/mL, and the ID50 value was 0.17 mumol/mL.

    Compounds 1 and 2 were also assayed with the mutagen 2- (2-furyl) - 3- (5-nitro-2-furyl) acrylamide (furylfuramide) and activated Trp-P-1.

    In addition to the antimutagenic activities of daidzein and genistein against Trp-P-1, frylfuramide and activated Trp-P-1 were assayed by an Ames test using S. typhimurium TA100.

    Mots-clés Pascal : Méthode étude, Mutation, Test Ames, Glycine max, Leguminosae, Dicotyledones, Angiospermae, Spermatophyta, Soja, Graine, Isoflavone dérivé, Salmonella typhimurium, Enterobacteriaceae, Bactérie, Mutagène, Antimutagène, Légumineuse grain, Isolement chimique, Anticancéreux, Expression génique, Chromotest SOS, Daidzéine, Génistéine, Souche TA1535/pSK1002

    Mots-clés Pascal anglais : Investigation method, Mutation, Ames test, Glycine max, Leguminosae, Dicotyledones, Angiospermae, Spermatophyta, Soybean, Seeds, Isoflavone derivatives, Salmonella typhimurium, Enterobacteriaceae, Bacteria, Mutagen, Antimutagen, Grain legume, Chemical isolation, Antineoplastic agent, Gene expression, SOS chromotest

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0443495

    Code Inist : 002B30A02A. Création : 22/03/2000.