The possible interference of hexachlorobenzene and octachlorostyrene (i.e., thermal byproducts from hexachloroethane in aluminum degassing) with porphyrin metabolism was investigated in exposed workers.
Urine specimens from 9 male aluminum foundry workers (i.e., smelters) at 6 different companies and from 18 controls-matched for sex, age, residence, and socioeconomic status-were analyzed for total porphyrins and porphyrin isomers.
Workers exposed to hexachlorobenzene and octachlorostyrene had a statistically significant increase in urinary total porphyrins, compared with controls (mean ± standard deviation : 13.63 ± 11.13 mumol/mol creatinine and 6.24 ± 3.84 mumol/mol creatinine, respectively ; p=02).
The authors attributed the results mainly to differences in excretion of coproporphyrins-notably coproporphyrin III.
Erythrocyte uroporphyrinogen decarboxylase activity was similar in both groups.
There was a high correlation between levels of hexachlorobenzene and octachlorostyrene, respectively, in plasma and urinary excretion of porphyrins ; these findings, however, relied heavily on 1 subject for whom extreme values were obtained.
The results indicated that occupational exposure to hexachlorobenzene and octachlorostyrene in aluminum degassing with hexachloroethane may affect porphyrin metabolism in a manner consistent with early secondary coproporphyrinuria-the first recognized step in the development of chronic hepatic porphyria. (...)
Mots-clés Pascal : Solvant organique, Toxicité, Exposition professionnelle, Médecine travail, Homme, Industrie métallurgique, Fonderie, Porphyrine, Dégazage, Chlore Composé organique, Métabolisme pathologie, Benzène(perchloro), Styrène(octachloro), Ethane(perchloro)
Mots-clés Pascal anglais : Organic solvent, Toxicity, Occupational exposure, Occupational medicine, Human, Metallurgical industry, Foundry, Porphyrin, Degassing, Chlorine Organic compounds, Metabolic diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0442063
Code Inist : 002B03L04. Création : 22/03/2000.