Porphyrin status in aluminum foundry workers exposed to hexachlorobenzene and octachlorostyrene.
The possible interference of hexachlorobenzene and octachlorostyrene (i.e., thermal byproducts from hexachloroethane in aluminum degassing) with porphyrin metabolism was investigated in exposed workers.
Urine specimens from 9 male aluminum foundry workers (i.e., smelters) at 6 different companies and from 18 controls-matched for sex, age, residence, and socioeconomic status-were analyzed for total porphyrins and porphyrin isomers.
Workers exposed to hexachlorobenzene and octachlorostyrene had a statistically significant increase in urinary total porphyrins, compared with controls (mean ± standard deviation : 13.63 ± 11.13 mumol/mol creatinine and 6.24 ± 3.84 mumol/mol creatinine, respectively ; p=02).
The authors attributed the results mainly to differences in excretion of coproporphyrins-notably coproporphyrin III.
Erythrocyte uroporphyrinogen decarboxylase activity was similar in both groups.
There was a high correlation between levels of hexachlorobenzene and octachlorostyrene, respectively, in plasma and urinary excretion of porphyrins ; these findings, however, relied heavily on 1 subject for whom extreme values were obtained.
The results indicated that occupational exposure to hexachlorobenzene and octachlorostyrene in aluminum degassing with hexachloroethane may affect porphyrin metabolism in a manner consistent with early secondary coproporphyrinuria-the first recognized step in the development of chronic hepatic porphyria. (...)
Mots-clés Pascal : Solvant organique, Toxicité, Exposition professionnelle, Médecine travail, Homme, Industrie métallurgique, Fonderie, Porphyrine, Dégazage, Chlore Composé organique, Métabolisme pathologie, Benzène(perchloro), Styrène(octachloro), Ethane(perchloro)
Mots-clés Pascal anglais : Organic solvent, Toxicity, Occupational exposure, Occupational medicine, Human, Metallurgical industry, Foundry, Porphyrin, Degassing, Chlorine Organic compounds, Metabolic diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0442063
Code Inist : 002B03L04. Création : 22/03/2000.