There are few data concerning the epidemiology of H. pylori in patients on chronic haemodialysis (HD) treatment.
These surveys concerned small populations and were made with ELISA technique.
However, ELISA-based assays do not differentiate between strains of H. pylori that are associated with ulcers.
Recent literature reports that formation of ulcers correlates strongly with the expression of cytotoxin-associated protein (CagA) and vacuolating cytotoxin (VacA) of H. pylori.
A novel serological test (RIBA H. pylori strip immunoblot assay (SIA)) has been recently introduced, it uses the H. pylori lysate (Lys) along with two additional purified recombinant antigens derived from CagA and VacA of H. pylori.
To study the epidemiology of H.
Pylori using RIBA H. pylori SIA among chronic HD patients and blood donors as a control group.
In addition, the activity of H. pylori was analysed by immunoblot technique in a group of patients with documented ulcers and normal renal function.
The prevalence of antibody towards H. pylori among HD patients, blood donors, and patients with documented ulcers was 56% (127/228), 53% (84/158), and 100% (21/21) respectively ; the difference was significant (P=0.0001).
The frequency of anti-H. pylori-positive individuals was significantly higher in patients with documented ulcers than HD patients and blood donors, 21/21 (100%) vs 211/386 (55%), P=0.0001. (...)
Mots-clés Pascal : Insuffisance rénale, Chronique, Hémodialyse, Ulcère, Gastroduodénal, Helicobacter pylori, Spirillaceae, Spirillales, Bactérie, Bactériose, Infection, Traitement, Complication, Epidémiologie, Homme, Appareil urinaire pathologie, Rein pathologie, Epuration extrarénale, Appareil digestif pathologie, Estomac pathologie, Intestin pathologie
Mots-clés Pascal anglais : Renal failure, Chronic, Hemodialysis, Ulcer, Gastroduodenal, Helicobacter pylori, Spirillaceae, Spirillales, Bacteria, Bacteriosis, Infection, Treatment, Complication, Epidemiology, Human, Urinary system disease, Kidney disease, Extrarenal dialysis, Digestive diseases, Gastric disease, Intestinal disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0437835
Code Inist : 002B27B03. Création : 22/03/2000.