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  1. Tuberculosis II : the failure of the BCG vaccine.

    Article - En anglais

    BCG (bacille Calmette-Guérin) is an attenuated pathogen characterized by its capacity to induce cellular and humoral immune responses primarily against a nonpeptidic antigen, lipoarabinomannan.

    Immune responses against this substance contribute to the immunoprotection of the patient if the production of IL-2 and INF-gamma is not impaired.

    The most adequate production of INF-gamma and IL-2 is obtained by immunoreactivity against proteinic antigens.

    The formation of IgG-type antibodies and of cellular immunity against mycobacterial peptidic and proteinic antigens is an additional immunological response essential for a good protection.

    This is achieved by the BCG vaccine in only a small proportion of the vaccinees.

    A vaccine adjuvant that also finds application as an immunotherapeutic agent is composed of proteinic antigens such as sonicates of Mycobacterium vaccae and antigen 60 of Mycobacterium bovis.

    These enhance the beneficial Th1-pole of the immune response.

    In addition, A60 induces the formation of antibodies against species-specific proteinic antigens.

    Despite the questioning of its innocuousness and efficacy, the BCG vaccine was imposed worldwide in 1950 by medical and political organizations that showed no concern for these questions. (...)

    Mots-clés Pascal : Tuberculose, Mycobactériose, Bactériose, Infection, Mycobacterium tuberculosis, Mycobacteriaceae, Mycobacteriales, Actinomycetes, Bactérie, BCG, Vaccin, Vaccination, Immunoprophylaxie, Prévention, Inefficacité, Homme

    Mots-clés Pascal anglais : Tuberculosis, Mycobacterial infection, Bacteriosis, Infection, Mycobacterium tuberculosis, Mycobacteriaceae, Mycobacteriales, Actinomycetes, Bacteria, BCG, Vaccine, Vaccination, Immunoprophylaxis, Prevention, Inefficiency, Human

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0437815

    Code Inist : 002B05B02O. Création : 22/03/2000.