Background Because many persons with chronic hepatitis C virus (HCV) infection are asymptomatic, population-based serologic studies are needed to estimate the prevalence of the infection and to develop and evaluate prevention efforts.
Methods We performed tests for antibody to HCV (anti-HCV) on serum samples from 21,241 persons six years old or older who participated in the third National Health and Nutrition Examination Survey, conducted during 1988 through 1994.
We determined the prevalence of HCV RNA by means of nucleic acid amplification and the genotype by means of sequencing.
Results The overall prevalence of anti-HCV was 1.8 percent, corresponding to an estimated 3.9 million persons nationwide (95 percent confidence interval, 3.1 million to 4.8 million) with HCV infection.
Sixty-five percent of the persons with HCV infection were 30 to 49 years old.
Seventy-four percent were positive for HCV RNA, indicating that an estimated 2.7 million persons in the United States (95 percent confidence interval, 2.4 million to 3.0 million) were chronically infected, of whom 73.7 percent were infected with genotype (56.7 percent with genotype 1a, and 17.0 percent with genotype 1b).
Among subjects 17 to 59 years of age, the strongest factors independently associated with HCV infection were illegal drug use and high-risk sexual behavior. (...)
Mots-clés Pascal : Hépatite virale C, Virose, Infection, Epidémiologie, Prévalence, Exploration immunologique, Sérologie, Génotype, Facteur risque, Etats Unis, Amérique du Nord, Amérique, Homme, Appareil digestif pathologie, Foie pathologie
Mots-clés Pascal anglais : Viral hepatitis C, Viral disease, Infection, Epidemiology, Prevalence, Immunological investigation, Serology, Genotype, Risk factor, United States, North America, America, Human, Digestive diseases, Hepatic disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0437031
Code Inist : 002B30A01A2. Création : 22/03/2000.