Many North American arctic communities are characterized by risk markers associated with Helicobacter pylori (H. pylori) infection, including overcrowded housing and inadequate water supply and sanitation systems.
Our aim was to determine the seroprevalence of H. pylori infection in two traditional Inuit communities in the central Canadian arctic and to test for the presence of H. pylori, by polymerase chain reaction (PCR), in local water supplies.
Samples of venous whole blood from adults and capillary blood from children were collected and analyzed by enzyme immunoassay and Helisal Rapid Test, respectively, for IgG antibody to H. pylori.
Antibodies to CagA were detected by enzyme immunoassay, and ABO and Lewis antigens were also determined.
Demographic and clinical information were collected by questionnaire.
Water samples from each community were tested for H. pylori by PCR.
One hundred-thirty (50.8%) of 256 subjects from the two communities were positive for H. pylori IgG antibodies.
Seropositive subjects were more likely to be male, compared with seronegative individuals (p=0.01).
Antibody status did not differ with respect to age, community, alcohol or cigarette use, number of persons per household, gastrointestinal complaints or previous investigations, medications, or presence of blood group O, Lewis a-b+CagA antibodies were detected in 78 (61.9%) of 126 H. pylori-seropositive subjects tested ; however, 41 (35.3%) of 116 H. (...)
Mots-clés Pascal : Gastrite, Bactériose, Infection, Helicobacter pylori, Spirillaceae, Spirillales, Bactérie, Séropositivité, Facteur risque, Hygiène, Epidémiologie, Homme, Appareil digestif pathologie, Estomac pathologie, Inuk
Mots-clés Pascal anglais : Gastritis, Bacteriosis, Infection, Helicobacter pylori, Spirillaceae, Spirillales, Bacteria, Seropositivity, Risk factor, Hygiene, Epidemiology, Human, Digestive diseases, Gastric disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0436686
Code Inist : 002B30A01A2. Création : 22/03/2000.