Context Several observational epidemiological studies report an association of pregnancy and obstetric complications with development of antisocial personality disorder (ASPD) in offspring.
However, the precise nature and timing of the hypothesized biological insults are not known.
Objective To test whether severe matemal nutritional deficiency early in gestation is associated with risk for ASPD in offspring.
Design and Setting Retrospective cohort study.
From October 1944 to May 1945, the German army blockaded food supplies to the Netherlands, subjecting the western Netherlands first to moderate (official food rations, 4200-6300 kJ/d) then to severe (<4200 kJ/d) nutritional deficiency.
The north and south were subjected to moderate nutritional deficiency only.
Participants Dutch men born in large urban areas in 1944-1946 who were given psychiatric examinations for military induction at age 18 years (N=100 543) were classified by the degree and timing of their prenatal exposure to nutritional deficiency based on their birthdate and birthplace.
Main Outcome Measure Diagnosis of ASPD by psychiatric interview at time of medical examination for military induction, using the International Classification of Diseases, Sixth Revision (ICD-6).
Results Men exposed prenatally to severe maternal nutritional deficiency during the first and/or second trimesters of pregnancy exhibited increased risk for ASPD (adjusted odds ratio [OR], 2.5 ; 95% confidence interval [CI], 1.5-4.2). (...)
Mots-clés Pascal : Malnutrition, Homme, Femelle, Gestation, Famine, Prénatal, Personnalité antisociale, Enfant, Adulte jeune, Facteur risque, Trouble nutrition, Gestation pathologie, Trouble personnalité
Mots-clés Pascal anglais : Malnutrition, Human, Female, Pregnancy, Famine, Prenatal, Antisocial personality, Child, Young adult, Risk factor, Nutrition disorder, Pregnancy disorders, Personality disorder
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0436657
Code Inist : 002B18C09. Création : 22/03/2000.