Previous studies suggested that diabetes mellitus may lower serum vitamin C concentrations, but most of these studies used clinic-based populations with established diabetes of varying duration and did not adjust for important covariates.
Using a population-based sample and adjusting for important covariates, we asked whether serum vitamin C concentrations in persons with newly diagnosed diabetes differed from those in persons without diabetes.
Data were obtained from the third National Health and Nutrition Examination Survey (1988-1994).
Serum vitamin C was assayed by using reversed-phase HPLC with multiwave-length detection.
Diabetes status (n=237 persons with diabetes ; n=1803 persons without diabetes) was determined by oral-glucose-tolerance testing of the sample aged 40-74 y. Results : After adjustment for age and sex, mean serum vitamin C concentrations were significantly lower in persons with newly diagnosed diabetes than in those without diabetes.
After adjustment for dietary intake of vitamin C and other important covariates, however, mean concentrations did not differ according to diabetes status.
When assessing serum vitamin C concentrations by diabetes status in the future, researchers should measure and account for all factors that influence serum vitamin C concentrations.
Mots-clés Pascal : Analyse quantitative, Acide ascorbique, Plasma sanguin, Régime alimentaire, Diabète insulinodépendant, Diabète non insulinodépendant, Epidémiologie, Etats Unis, Amérique du Nord, Amérique, Vitamine, Alimentation, Endocrinopathie, Immunopathologie, Maladie autoimmune, Homme
Mots-clés Pascal anglais : Quantitative analysis, Ascorbic acid, Blood plasma, Diet, Insulin dependent diabetes, Non insulin dependent diabetes, Epidemiology, United States, North America, America, Vitamin, Feeding, Endocrinopathy, Immunopathology, Autoimmune disease, Human
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0434987
Code Inist : 002B21E01A. Création : 22/03/2000.