An unusual cluster of 8 breast cancer and 8 other malignant tumor cases (ovarian, uterus, lung, colon and brain tumors and malignant melanoma) developed in a period of 12 years among 98 nurses exposed to ethylene oxide (EtOx) for 5-15 years in a unit using gas sterilizer in a hospital of the archiepiscopal city of Eger, Hungary.
EtOx concentration in air samples of the working area varied from 5 to 150 mg/m3.
The question was, if there was any causal relationship between the elevated incidence of breast cancer and the EtOx exposure, the other possibility was, that this cluster appeared accidentally.
EtOx is a human carcinogen, however, no increased breast cancer incidence in EtOx-exposed subjects was reported in the literature.
We followed up for two consecutive years the 27 non cancer patients, EtOx-exposed nurses and 11 unexposed hospital controls with the aid of a multiple genotoxicology monitor including chromosomal aberration, sister-chromatide exchange, HPRT point mutation and DNA repair studies.
The results were compared with data from 30 local historical controls, 48 historical controls from Budapest, 14 hospital controls and 9 EtOx exposed nurses from Budapest.
Significantly high chromosome aberration yields (especially chromosome type exchanges) were alike detected in EtOx-exposed and the two other control groups in Eger. (...)
Mots-clés Pascal : Infirmier, Homme, Femelle, Facteur risque, Personnel sanitaire, Tumeur maligne, Glande mammaire, Irradiation ionisante, Oxirane, Exposition professionnelle, Toxicité, Radon, Glande mammaire pathologie
Mots-clés Pascal anglais : Nurse, Human, Female, Risk factor, Health staff, Malignant tumor, Mammary gland, Ionizing irradiation, Ethylene oxide, Occupational exposure, Toxicity, Radon, Mammary gland diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0433290
Code Inist : 002B30A05. Création : 22/03/2000.