In a 4-year follow-up study, patients with acute sporadic non-A, non-B (NANB) hepatitis were evaluated to determine the etiology and natural history of the disease.
Acute hepatitis C virus (HCV) was detected in 13 of 43 (30%) of patients, anti-hepatitis E virus (HEV) IgG in 5 (12%), and 25 (58%) were considered non-A-E.
The HCV RNA was detected in all HCV patients but none of the non-A-E cases.
The initial clinical and biochemical presentation of the HCV and non-A-E cases was quite similar, although 2 of the non-A-E patients had severe disease.
The 5 patients who were found to be anti-HEV IgG-reactive recovered within 6 months of follow-up.
Of the 13 HCV cases, alanine transaminase (ALT) levels returned to normal in 7 (53.8%), while 6 (46.2%) continued to show abnormal ALT after 6 months of follow-up.
However, 9 (69.2%) of them remained HCV-RNA-positive, denoting virological/biochemical dissociation.
Long-term follow-up showed a reappearance of HCV RNA in 2 of the 4 patients who were in virological remission performing 84% of chronicity rate.
Acute non-A-E hepatitis patients were less likely to evolve toward chronicity, as compared with acute HCV cases (16% vs. 84% ; P=0001).
Only 4 (16%) of the non-A-E patients were hepatitis G virus (HGV) - RNA-positive.
Concerning risk factors for acquiring parenterally transmitted viruses, tattooing was the only one that could be associated with HCV transmission (P=002). (...)
Mots-clés Pascal : Hépatite virale ni A ni B, Virose, Infection, Aigu, Sporadique, Epidémiologie, Etiologie, Histoire familiale, Evolution, Nord est, Brésil, Amérique du Sud, Amérique, Etude cohorte, Facteur risque, Homme, Appareil digestif pathologie, Foie pathologie, Organisation santé
Mots-clés Pascal anglais : Non A non B viral hepatitis, Viral disease, Infection, Acute, Sporadic, Epidemiology, Etiology, Family story, Evolution, Northeast, Brazil, South America, America, Cohort study, Risk factor, Human, Digestive diseases, Hepatic disease, Public health organization
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0431689
Code Inist : 002B05C02G. Création : 22/03/2000.